Therapeutic Potential of Trigonella foenum-graecum Extract in Restoring Phenylhydrazine-Induced Hematological Alterations in Mus musculus

Anaemia remains a major global health issue, necessitating the exploration of alternative therapeutic interventions. This study evaluates the haematological effects of Trigonella foenum-graecum (fenugreek) extract in anaemia-induced Swiss albino mice (Mus musculus), with focus on its potential to restore haematological parameters. Anaemia was induced using ferrous sulphate, leading to significant reductions in haemoglobin (Hb), hematocrit (Hct), and red blood cell (RBC) counts, accompanied by alterations in white blood cell (WBC) counts and platelet levels. T. foenum-graecum extract supplementation resulted in substantial improvements in Hb, Hct, and RBC counts while modulating WBC and platelet levels, indicating its role in erythropoiesis and immune regulation. The observed hematopoietic effects are attributed to the bioactive compounds in fenugreek, including flavonoids, saponins, and iron, which contribute to its antioxidant and anti-inflammatory properties. The results suggest that T. foenum-graecum could serve as a promising natural remedy for anaemia, warranting further clinical investigations.