MiR-23b-3p Promotes the Progression of Renal Cell Carcinoma and Lipid Accumulation via Regulating SREBP-1c
In this study, we investigated the role of miR-23b-3p in renal cell carcinoma (RCC) progression and lipid accumulation by regulating SREBP-1c, aiming to identify potential biomarkers and therapeutic targets for RCC management. We assessed miR-23b-3p and SREBP-1c expressions in RCC cell lines ACHN, A498, and Caki-2, compared with normal HRCE cells. A498 cells showed notably elevated miR-23b-3p and SREBP-1c levels. Inhibition of miR-23b-3p reduced A498 cell viability, migration, invasion, FASN, ACC1, SCD1, and SREBP-1c expression, and triglyceride content. Overexpression of SREBP-1c reversed the effects of miR-23b-3p downregulation on cell viability and triglyceride levels in A498 cells. Our findings highlight the role of miR-23b-3p in promoting RCC progression and lipid accumulation via SREBP-1c activation, providing potential avenues for novel biomarkers and therapeutic targets in RCC management.
Authors
- Fangning Liu
- Xuheng Liu (ORCID: https://orcid.org/0009-0000-7042-7075)
- Xiaorong Yang (ORCID: https://orcid.org/0000-0001-9866-3029)
- Ju Guo
- Hua Yang (ORCID: https://orcid.org/0000-0002-0153-582X)
- Jinrun Han
Institutions
- Union Hospital (HK)
- Nanchang University (CN)
- First Affiliated Hospital of Nanchang University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Science of Advanced Materials
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1166/sam.2024.4638
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00