High Baseline Plasma Anthranilic Acid Predicts Remission Upon Acute-Series Ketamine Infusion for Treatment-Resistant Depression

Elevated AA levels and AA-based biomarker ratios predicted ketamine remission in patients with TRD, supporting biomarker-driven personalized treatment. These findings highlight immunometabolic mechanisms in ketamine response.

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Publication Details

Journal
Biological Psychiatry Global Open Science
Published
2025-04-12
DOI
https://doi.org/10.1016/j.bpsgos.2025.100503
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
0.00
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article

High Baseline Plasma Anthranilic Acid Predicts Remission Upon Acute-Series Ketamine Infusion for Treatment-Resistant Depression

Colt Capan, Erik Nelson, Sagar V. Parikh, Zachary Madaj et al.
Biological Psychiatry Global Open Science
Treatment of Major Depression
article

High Baseline Plasma Anthranilic Acid Predicts Remission Upon Acute-Series Ketamine Infusion for Treatment-Resistant Depression

Colt Capan, Erik Nelson, Sagar V. Parikh, Zachary Madaj, Mark A. Frye, Owen M. Wolkowitz, Balwinder Singh, Ryan D. Sheldon, Jennifer L. Vande Voort, Louis Nykamp, Gustavo C. Medeiros, William V. Bobo, Eric D. Achtyes, Fernando S. Goes, Gregory F. Oxenkrug, Rif S. El‐Mallakh, Lena Brundin, Michael E. Thase, Stephen Murata, John F. Greden
article en

Abstract

Elevated AA levels and AA-based biomarker ratios predicted ketamine remission in patients with TRD, supporting biomarker-driven personalized treatment. These findings highlight immunometabolic mechanisms in ketamine response.

Biological Psychiatry Global Open ScienceVol. 5(4)
Grand Rapids Community College (US), Tufts University (US), University of Maryland, Baltimore (US), Pine Rest Christian Mental Health Services (US), Van Andel Institute (US), Mayo Clinic (US), Western Michigan University (US), University of Louisville (US), Johns Hopkins University (US), University of California, San Francisco (US), University of Michigan (US), Jacksonville College (US), WinnMed (US), Mayo Clinic in Florida (US), Stryker (United States) (US), University of Cincinnati (US), University of Pennsylvania (US), Michigan State University (US)
Openalex Percentile: Top 91%
Treatment of Major Depression
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