High Baseline Plasma Anthranilic Acid Predicts Remission Upon Acute-Series Ketamine Infusion for Treatment-Resistant Depression
Elevated AA levels and AA-based biomarker ratios predicted ketamine remission in patients with TRD, supporting biomarker-driven personalized treatment. These findings highlight immunometabolic mechanisms in ketamine response.
Authors
- Colt Capan (ORCID: https://orcid.org/0000-0001-9637-9470)
- Erik Nelson (ORCID: https://orcid.org/0000-0002-5229-2370)
- Sagar V. Parikh (ORCID: https://orcid.org/0000-0003-4817-3042)
- Zachary Madaj (ORCID: https://orcid.org/0000-0003-2330-0500)
- Mark A. Frye (ORCID: https://orcid.org/0000-0001-6997-4215)
- Owen M. Wolkowitz (ORCID: https://orcid.org/0000-0003-0655-5042)
- Balwinder Singh (ORCID: https://orcid.org/0000-0001-7062-8192)
- Ryan D. Sheldon (ORCID: https://orcid.org/0000-0002-1573-9719)
- Jennifer L. Vande Voort
- Louis Nykamp
- Gustavo C. Medeiros (ORCID: https://orcid.org/0000-0002-0091-1192)
- William V. Bobo (ORCID: https://orcid.org/0000-0002-5674-3079)
- Eric D. Achtyes (ORCID: https://orcid.org/0000-0001-8939-1535)
- Fernando S. Goes (ORCID: https://orcid.org/0000-0001-6262-8264)
- Gregory F. Oxenkrug (ORCID: https://orcid.org/0000-0002-7193-9117)
- Rif S. El‐Mallakh (ORCID: https://orcid.org/0000-0002-4992-8016)
- Lena Brundin (ORCID: https://orcid.org/0000-0002-8327-6242)
- Michael E. Thase (ORCID: https://orcid.org/0000-0002-6403-0861)
- Stephen Murata
- John F. Greden
Institutions
- Grand Rapids Community College (US)
- Tufts University (US)
- University of Maryland, Baltimore (US)
- Pine Rest Christian Mental Health Services (US)
- Van Andel Institute (US)
- Mayo Clinic (US)
- Western Michigan University (US)
- University of Louisville (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- University of Michigan (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
- Stryker (United States) (US)
- University of Cincinnati (US)
- University of Pennsylvania (US)
- Michigan State University (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100503
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00