The effect of Alzheimer's disease genetic factors on limbic white matter microstructure
AD risk variants in TMEM106B, PTK2B, WNT3, and APOE genes showed distinct associations with limbic FW-corrected WM microstructure metrics. Interaction effects were observed between MS4A6A variants and cognitive status. PGS for AD was associated with higher FW content in the limbic system.
Authors
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Nancy R. Newlin (ORCID: https://orcid.org/0000-0003-3714-4684)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Karthik Ramadass (ORCID: https://orcid.org/0000-0002-4610-3860)
- Arthur W. Toga (ORCID: https://orcid.org/0000-0001-7902-3755)
- T. Bryan Jackson (ORCID: https://orcid.org/0000-0002-6318-1916)
- Niranjana Shashikumar
- Sarah Biber
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Chenyu Gao (ORCID: https://orcid.org/0000-0003-2098-3035)
- Barbara B. Bendlin (ORCID: https://orcid.org/0000-0002-0580-9875)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0003-0756-5007)
- Mohamad Habes
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Di Wang (ORCID: https://orcid.org/0000-0003-0460-1463)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Lori L. Beason‐Held (ORCID: https://orcid.org/0000-0001-9057-6270)
- Praitayini Kanakaraj (ORCID: https://orcid.org/0000-0002-9979-217X)
- Guray Erus
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Kurt G. Schilling (ORCID: https://orcid.org/0000-0003-3686-7645)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Michael E. Kim (ORCID: https://orcid.org/0009-0006-3562-2688)
- Tianyuan Yao (ORCID: https://orcid.org/0000-0002-1848-079X)
- Angela Lee Jefferson (ORCID: https://orcid.org/0000-0002-8245-0587)
- Yuankai Huo (ORCID: https://orcid.org/0000-0002-2096-8065)
- Kimberly R. Pechman (ORCID: https://orcid.org/0000-0003-0596-8064)
- Bennett A. Landman (ORCID: https://orcid.org/0000-0001-5733-2127)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Alaina Durant
- Dimitrios Zaras
- Zhiyuan Li (ORCID: https://orcid.org/0000-0002-4091-6342)
- Panpan Zhang (ORCID: https://orcid.org/0000-0002-8211-5930)
- Yang An (ORCID: https://orcid.org/0000-0002-3312-7265)
- Paul M. Thompson (ORCID: https://orcid.org/0000-0002-4720-8867)
- Marilyn Albert
- Nazirah Mohd Khairi (ORCID: https://orcid.org/0000-0003-2180-3200)
- Sterling C. Johnson
- David A. Bennett
- Aditi Sathe
- Yisu Yang
- Anna Lorenz (ORCID: https://orcid.org/0009-0003-4344-7486)
- Abigail W. Workmeister
Institutions
- University of Southern California (US)
- Rush University Medical Center (US)
- National Institutes of Health (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- Illinois Institute of Technology (US)
- Vanderbilt University (US)
- University of Washington (US)
- University of California System (US)
- Institute for Neurodegenerative Disorders (US)
- National Institute on Aging (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70130
- Citations
- 5
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 6.80
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Alzheimer's Drug Discovery Foundation
- Eli Lilly and Company
- Pfizer
- Illinois Department of Public Health
- Biogen
- Vanderbilt University
- Meso Scale Diagnostics
- BioClinica
- Novartis Pharmaceuticals Corporation
- Takeda Pharmaceutical Company
- Northern California Institute for Research and Education
- Vanderbilt University Medical Center
- Fujirebio Europe
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- GE Healthcare
- Canadian Institutes of Health Research
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering