Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells
We established an efficient small molecule-based method to differentiate hESCs into ameloblast-like cells through the concerted modulation of RA, BMP, WNT, and NOTCH signaling pathways, potentially advancing research in enamel and tooth regeneration.
Authors
- Chunli Tian
- J.L. Ruan (ORCID: https://orcid.org/0009-0000-9819-5122)
- Ruilin Sun (ORCID: https://orcid.org/0000-0002-7564-1051)
- Chao Yan (ORCID: https://orcid.org/0000-0003-0527-5719)
- Qiannan Dong (ORCID: https://orcid.org/0009-0005-4441-5237)
- Ximei Zhu (ORCID: https://orcid.org/0000-0003-3271-1328)
- Yinghua Zhao (ORCID: https://orcid.org/0000-0003-2101-392X)
- Zhongbo Liu (ORCID: https://orcid.org/0000-0003-0075-1261)
- Xiaofan Bai (ORCID: https://orcid.org/0009-0004-6796-3773)
- Jianghong Gao
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s13287-025-04294-6
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Strong