Predominant right temporal and frontal brain atrophy and progressive behavioral dementia. A case of prion gene mutation (PRNP)
Heterozygous c.623G>A (p.Arg208His) genotype may be responsible for FTD phenotype. This case shows the necessity of genetic testing for possible mutations in the prion gene in patients with bvFTD and positive family history of dementia.
Authors
- Andreas Kyrozis (ORCID: https://orcid.org/0000-0003-2689-6426)
- Efthalia Angelopoulou (ORCID: https://orcid.org/0000-0002-1426-3384)
- Christos Κroupis (ORCID: https://orcid.org/0000-0002-5876-2599)
- Christos Koros (ORCID: https://orcid.org/0000-0001-5806-0717)
- Evangelia Stanitsa (ORCID: https://orcid.org/0000-0001-5448-3675)
- A. Koulouris (ORCID: https://orcid.org/0000-0003-1012-4675)
- Sokratis G. Papageorgiou (ORCID: https://orcid.org/0000-0001-8863-3635)
- Vasilios C. Constantinides (ORCID: https://orcid.org/0000-0001-7432-5009)
- Georgios Velonakis (ORCID: https://orcid.org/0000-0002-0050-284X)
- Evangelos Koumasopoulos (ORCID: https://orcid.org/0009-0008-9445-7082)
- Leonidas Stefanis
- Chrysoula Michaletou
- Vasiliki Barbarousi
- Savvas Konstantinos Alevetsovitis
Institutions
- National and Kapodistrian University of Athens (GR)
- Eginition Hospital (GR)
Publication Details
- Journal
- Neurocase
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1080/13554794.2025.2491746
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00