Erythropoietin delivery through kidney organoids engineered with an episomal DNA vector
Kidney organoids modified by EPO S/MAR DNA vector allow stable long-term delivery of EPO. The observed physiological effects following the implantation of EPO + organoids underscore the potential of gene-edited kidney organoids for endocrine restoration therapy.
Authors
- Zhaoyu Du
- Richard P. Harbottle (ORCID: https://orcid.org/0000-0002-3332-8024)
- Carla C. Baan (ORCID: https://orcid.org/0000-0003-2274-2788)
- Matthew W. Urban (ORCID: https://orcid.org/0000-0003-1360-4287)
- Marlies E. J. Reinders (ORCID: https://orcid.org/0000-0001-9543-567X)
- Thierry van den Bosch (ORCID: https://orcid.org/0000-0002-7223-4565)
- Marian C. Clahsen‐van Groningen (ORCID: https://orcid.org/0000-0003-0565-9560)
- Adam Hartley (ORCID: https://orcid.org/0000-0003-1431-2200)
- Bram C. J. van der Eerden (ORCID: https://orcid.org/0000-0003-4403-6497)
- Jaap Mulder (ORCID: https://orcid.org/0000-0001-5404-9203)
- Danielle Ratsma (ORCID: https://orcid.org/0000-0003-3198-5394)
- Martin J. Hoogduijn (ORCID: https://orcid.org/0000-0002-0217-8254)
- Amanda Bas-Cristóbal Menéndez (ORCID: https://orcid.org/0000-0002-6854-3269)
- Marijke Koedam
- Joost H. Gribnau (ORCID: https://orcid.org/0000-0001-5645-4691)
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Erasmus MC Cancer Institute (NL)
- RWTH Aachen University (DE)
- Rotterdam University of Applied Sciences (NL)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s13287-025-04282-w
- Citations
- 2
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 1.61