Oral Prednisolone, Apremilast and Human Umbilical Cord Mesenchymal Stem Cells in the Management of Pemphigus Foliaceus

This case report showed a 60-year-old male with Pemphigus foliaceus (PF), complicated by hypertension, diabetes, and hepatitis B, for whom traditional treatments posed potential risks. The regimen included prednisone, human umbilical cord mesenchymal stem cells (UC-MSCs), and apremilast, showing several advancements: UC-MSCs addressed PF and comorbidities without reported side effects, accelerated steroid tapering substantially compared to apremilast monotherapy, and held superior benefits over hematopoietic stem cells. Over a 4-month follow-up, there was a marked improvement in the patient's condition, normalization of autoantibody levels, and an increase in regulatory T cells. Further research and extended monitoring are warranted to ascertain the findings' validity and applicability.