Potential predictive value of CD8A and PGF protein expression in gastric cancer patients treated with neoadjuvant immunotherapy
Through multiomics analysis, we discovered that CD8A is linked to enhanced treatment response and tumor regression. In contrast, PGF appears to exert adverse effects on treatment outcomes, suggesting a complex interplay of factors influencing the efficacy of immunoneoadjuvant therapy in gastric cancer.
Authors
- Tuo Wang (ORCID: https://orcid.org/0000-0002-9862-5038)
- Xiaojie Zhang (ORCID: https://orcid.org/0000-0002-6211-7576)
- Ting Lei (ORCID: https://orcid.org/0000-0003-2627-7318)
- Chengjuan Zhang (ORCID: https://orcid.org/0000-0002-0702-6890)
- Yongjun Guo
- Bin Ma (ORCID: https://orcid.org/0000-0002-0727-4536)
- Ning Li (ORCID: https://orcid.org/0000-0002-8388-5080)
- Wenhao Xu (ORCID: https://orcid.org/0000-0003-4136-5586)
- Minqing Wu
- Ruihua Bai
- Benling Xu (ORCID: https://orcid.org/0000-0001-9633-212X)
- Jing Yuan (ORCID: https://orcid.org/0000-0002-6936-7615)
- Tingjie Wang (ORCID: https://orcid.org/0000-0001-9238-0968)
- Xiance Tang
Institutions
- Murdoch University (AU)
- The University of Western Australia (AU)
- Zhengzhou University (CN)
- Henan University of Engineering (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s12885-025-14046-7
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Zhengzhou University
- Natural Science Foundation of Henan Province