The effect of total knee arthroplasty surgery on mean platelet volume, platelet count, and mean platelet volume/platelet count ratio

Objective: This study aims to investigate the effects of total knee arthroplasty (TKA) surgery on mean platelet volume (MPV), platelet count (Plt), and the MPV/Plt ratio. Methods: This retrospective study examined the data of 379 patients who underwent total knee arthroplasty at Konya City Hospital between January 1, 2023, and January 1, 2024. Preoperative and postoperative blood tests were analyzed at 12-24 hours (postop1) and 24-48 hours (postop2) intervals. MPV, Plt, and MPV/Plt ratio were recorded and compared. Repeated measures ANOVA test was used for statistical analysis. Results: A significant increase in MPV and MPV/Plt ratio and a significant decrease in Plt were observed in the postoperative period (p<0.001). Conclusion: The increase in MPV and the decrease in Plt after total knee arthroplasty may indicate an elevated risk of thromboembolic complications. Routine monitoring of MPV, Plt, and the MPV/Plt ratio could be necessary for the erly detection and management of these complications.