Perfusion index as a surrogate for lactate clearance as resuscitation endpoint in sepsis

Background Sepsis Remains one of the most common presentations in emergency departments. Fluid resuscitation is one pillar of management strategy. The perfusion index (PI), can be a valid surrogate for lactate clearance in this prospect. Aim To investigate the ability of the PerfuIndex as a novel, bedside, noninvasive resuscitation endpoint in sepsis patients. Patients and methods Our team designed a prospective observational study including a patient sample aged greater than or equal to 18 of both sexes, with clinically suspected sepsis. Participants underwent a categorization into two groups: group A resuscitated and group B nonresuscitated. Statistical analysis of observed changes in PI readings was conducted to estimate a correlation between both measurements, Lactate Clearance and delta PI. Results Cases underwent a categorization into two groups, group A (resuscitated, n =28) and group B (nonresuscitated, n =22). Serum lactate showed a significant reduction within the resuscitated group as opposed to the nonresuscitated group at 0 min and 120 min ( P <0.001). PI was significantly higher in the resuscitated group at 60, 90, and 120 min ( P <0.05). Delta-1 PI (0–60 min), and delta 2 PI (0–120 min) showed a significant elevation within the resuscitated group ( P =0.003 and <0.001). A positive association was documented between lactate clearance as well as delta 2 PI ( P <0.001). Delta 2 of PI can significantly predict fluid resuscitation in sepsis patients at a cut-off greater than 1.41 Conclusions PI could stand as a valid surrogate marker for evaluating the fluid resuscitation effectiveness in sepsis patients, potentially complementing, or even replacing more invasive monitoring techniques.