Factors associated with worsening interstitial fibrosis/tubular atrophy in lupus nephritis patients undergoing clinically indicated repeat kidney biopsy
Proliferative LN and the presence of crescents on index biopsies were associated with subsequent IFTA progression on repeat biopsies. This association indicates that glomerular damage is one of the major drivers of tubulointerstitial scarring in SLE. IFTA progression may, in turn, be the driving factor of poor treatment response and progression to chronic kidney disease.
Authors
- Maria Salgado Guerrero (ORCID: https://orcid.org/0000-0002-8950-9836)
- Alejandra Londoño Jimenez (ORCID: https://orcid.org/0000-0002-5339-5283)
- Daming Shao
- Anna Broder (ORCID: https://orcid.org/0000-0003-4772-3057)
- Shudan Wang (ORCID: https://orcid.org/0000-0002-8725-1974)
Institutions
- Albert Einstein College of Medicine (US)
- Hackensack University Medical Center (US)
- Montefiore Medical Center (US)
- Columbia University Irving Medical Center (US)
- McFarland Clinic - Jefferson (US)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1186/s12882-025-04108-0
- Citations
- 3
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- Rheumatology Research Foundation
- Lupus Research Alliance
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Center for Advancing Translational Sciences