Hydrogel Based on Bletilla Striata Polysaccharide for Sustained Sodium Danshensu Release for Wound Healing

<i>Bletilla striata</i> polysaccharide (BSP) is effective at healing wounds and has important application value in the research and development of biomedical materials. In this study, BSP, chitosan, and sodium β-glycerophosphate were used to generate a complex hydrogel with a very small pore size of 10-30 μm without the use of cross-linking agents. By improving the cross-linking density, the mechanical property defects caused by excessive BSP dissolution were overcome without affecting its physiological activity. Moreover, the small molecule Danshen sodium (SDSS) was loaded into the three-dimensional network of this hydrogel to form a hydrogel drug carrier system. SDSS could be released in the long term, and the total amount released after 53 h was 96.26 ± 2.57%. The BSP hydrogel had good water absorption (169.47 ± 4.54%) and bonding properties. In vitro studies confirmed that it has a good antibacterial performance and biocompatibility and the ability to promote cell proliferation (>200%) and migration. Molecular experiments confirmed that the hydrogel promotes collagen expression. In vivo experiments using a mouse wound healing model confirmed that the hydrogel has an excellent ability to promote wound healing, particularly during the first 7 days of the wound. The wound healing rate of the hydrogel group was higher than that of the blank group by 27.61% (<i>p</i> < 0.05), and the effect of the hydrogel to promote wound healing was confirmed by wound tissue staining.