Antiplatelet-anticoagulant, APAC, a mimic of endogenous heparin, is an antithrombotic with von Willebrand factor-mediated characteristics
The structure-function of APAC conveys dual and unique antiplatelet and anticoagulant actions in flowing blood over collagen and beyond. Our studies confirmed the inhibitory role of APAC on VWF functions and fibrin formation.
Authors
- Marja Lemponen
- Annukka Jouppila
- Riitta Lassila (ORCID: https://orcid.org/0000-0002-1911-3094)
- Taina Mattila
- Ilja Nevola
Institutions
- University of Helsinki (FI)
Publication Details
- Journal
- Thrombosis Research
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1016/j.thromres.2025.109318
- Citations
- 2
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.78