VEGF secreted by human dental pulp stem cell promotes spinal cord injury repair by inhibiting microglial pyroptosis through the PI3K/AKT pathway
Human DPSC-derived VEGF alleviates microglial pyroptosis via the PI3K/AKT signaling pathway, thereby contributing to the repair of SCI. Our study provides new insights into the potential for therapy of DPSCs and their secreted factors, particularly VEGF, offering new perspectives on the treatment of SCI.
Authors
- Yun Guan (ORCID: https://orcid.org/0000-0003-1321-6655)
- Guanghao Li (ORCID: https://orcid.org/0000-0001-9684-4037)
- Xinwei Zhang (ORCID: https://orcid.org/0000-0003-3679-0297)
- Liang Liu (ORCID: https://orcid.org/0000-0002-2824-7334)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-7017-5186)
- Xueming Chen (ORCID: https://orcid.org/0009-0001-8681-9660)
- Zihang Wang (ORCID: https://orcid.org/0000-0001-9032-5412)
- Tao Liu (ORCID: https://orcid.org/0009-0006-5688-5946)
- Nan Ding (ORCID: https://orcid.org/0000-0002-4977-4344)
- Ziqian Ma
Institutions
- Fujian Medical University (CN)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Beijing Luhe Hospital Affiliated to Capital Medical University (CN)
- Neurological Surgery (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1186/s12967-025-06388-4
- Citations
- 6
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Capital Medical University