Sex-based differences in Jumping to Conclusions: a multidimensional analysis of first-episode psychosis

Jumping to conclusions (JTC) bias is a hallmark cognitive bias in psychosis that involves hasty decision-making with limited evidence. Previous research has shown links between JTC and neurocognitive (NC), social cognitive (SC), metacognitive (MC), and clinical (CV) variables, but sex-based differences in these relationships remain understudied. This multicenter cross-sectional study included 121 first-episode psychosis (FEP) patients from nine Spanish mental health centers. Participants underwent comprehensive assessments of JTC, SC, NC, MC, and CV, and the interaction between JTC and sex was analysed. JTC-women attributed negative causes of events to themselves more often than non-JTC women and men, while JTC-men displayed more cognitive rigidity, slower processing speed, and better self-esteem compared to their non-JTC counterparts. Non-JTC-women showed better verbal memory recall. Logistic regression revealed distinct predictors for JTC by sex: women were influenced by negative internalization of events and visuospatial speed, while men's JTC was linked to errors in executive functions and memory. These results highlight the importance of sex-specific patterns in JTC and suggest that women might benefit from interventions targeting reflective thinking and social cognition, whereas men may need neurocognitive rehabilitation strategies.

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Publication Details

Journal
Schizophrenia
Published
2025-04-12
DOI
https://doi.org/10.1038/s41537-025-00579-0
Citations
3
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
4.41

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article

Sex-based differences in Jumping to Conclusions: a multidimensional analysis of first-episode psychosis

Luciana Díaz-Cutraro, Javier Rico, Marta Ferrer-Quintero, María Luisa Barrigón et al.
3 citations
Schizophrenia
Schizophrenia research and treatment
4.41
article

Sex-based differences in Jumping to Conclusions: a multidimensional analysis of first-episode psychosis

Luciana Díaz-Cutraro, Javier Rico, Marta Ferrer-Quintero, María Luisa Barrigón, Julia Sevilla‐Llewellyn‐Jones, Ester Lorente‐Rovira, Josep María Haro, Alfonso Gutiérrez‐Zotes, Raquel López‐Carrilero, Esther Pousa, Victoria Espinosa, Jordi Cid, Marina Videnović, Fermín González‐Higueras, Cárol Palma, Isabel Ruiz‐Delgado, Eva Grasa, Helena García‐Mieres, Steffen Moritz, María Lamarca, Ana Barajas
article en
3 citations

Abstract

Jumping to conclusions (JTC) bias is a hallmark cognitive bias in psychosis that involves hasty decision-making with limited evidence. Previous research has shown links between JTC and neurocognitive (NC), social cognitive (SC), metacognitive (MC), and clinical (CV) variables, but sex-based differences in these relationships remain understudied. This multicenter cross-sectional study included 121 first-episode psychosis (FEP) patients from nine Spanish mental health centers. Participants underwent comprehensive assessments of JTC, SC, NC, MC, and CV, and the interaction between JTC and sex was analysed. JTC-women attributed negative causes of events to themselves more often than non-JTC women and men, while JTC-men displayed more cognitive rigidity, slower processing speed, and better self-esteem compared to their non-JTC counterparts. Non-JTC-women showed better verbal memory recall. Logistic regression revealed distinct predictors for JTC by sex: women were influenced by negative internalization of events and visuospatial speed, while men's JTC was linked to errors in executive functions and memory. These results highlight the importance of sex-specific patterns in JTC and suggest that women might benefit from interventions targeting reflective thinking and social cognition, whereas men may need neurocognitive rehabilitation strategies.

SchizophreniaVol. 11(1)
Universidad Complutense de Madrid (ES), Universitat Autònoma de Barcelona (ES), Universitat Oberta de Catalunya (ES), Universität Hamburg (DE), Institut Pere Mata (ES), Hospital de Sant Pau (ES), Hospital General Universitario Gregorio Marañón (ES), Centro de Investigación Biomédica en Red de Salud Mental (ES), Hospital Clínico Universitario de Valencia (ES), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES), Maresme Health Consortium (ES), Institut de Recerca Biomèdica Catalunya Sud (ES), Hospital Regional Universitario de Málaga (ES), University Medical Center Hamburg-Eppendorf (DE), Spanish Clinical Research Network (ES), Complejo Hospitalario de Jaén (ES), Sant Joan de Déu Research Foundation (ES), Parc Sanitari Sant Joan de Déu (ES), Hospital de Mataró (ES), Spanish Ovarian Cancer Research Group (ES), Institut d'Assistència Sanitària (ES), Institut de Recerca Sant Pau (ES), Institut de Recerca Sant Joan de Déu, Universitat Ramon Llull (ES)
“la Caixa” Foundation, Ministerio de Ciencia, Innovación y Universidades, Consejería de Salud y Familias, Junta de Andalucía, Instituto de Salud Carlos III, European Regional Development Fund
Gender equality
Openalex Percentile: Top 6%
Schizophrenia research and treatment
4.41
DOIOpen Access PDFOpenAlex
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