Towards whole brain mapping of the hemodynamic response function

Functional magnetic resonance imaging time-series are conventionally processed by linear modelling the evoked response as the convolution of the experimental conditions with a stereotyped hemodynamic response function (HRF). However, the neural signal in response to a stimulus can vary according to task, brain region, and subject-specific conditions. Moreover, HRF shape has been suggested to carry physiological information. The BOLD signal across a range of sensorial and cognitive tasks was fitted using a sine series expansion, and modelled signals were deconvolved, thus giving rise to a task-specific deconvolved HRF (dHRF), which was characterized in terms of amplitude, latency, time-to-peak and full-width at half maximum for each task. We found that the BOLD response shape changes not only across activated regions and tasks, but also across subjects despite the age homogeneity of the cohort. Largest variabilities were observed in mean amplitude and latency across tasks and regions, while time-to-peak and full width at half maximum were relatively more consistent. Additionally, the dHRF was found to deviate from canonicity in several brain regions. Our results suggest that the choice of a standard, uniform HRF may be not optimal for all fMRI analyses and may lead to model misspecifications and statistical bias.