Comparison of effectiveness and efficacy of adverse drug events detection between mental health trigger tool and comprehensive medication review

Abstract Background Adverse drug events (ADEs) are a global issue that is caused due to widespread use of therapeutic drugs to manage chronic diseases alongside various comorbidities. Multiple tools have been devised to evaluate patients to avoid ADE incidence. Objectives The study aims to evaluate and compare the effectiveness and efficacy of the mental health trigger tool (MHTT) and comprehensive medication review (CMR) methods with respect to ADE detection. Methods The present study was a prospective observational study conducted in the psychiatry department of tertiary healthcare hospitals located in Coimbatore. The study was conducted over a period of 6 months. The records of 100 patients were included and the participants were assessed using the MHTT and CMR tools and the frequency of ADEs, their effectiveness, and efficacy were compared. One-way analysis of variance was utilized to determine the significance between categorical variables and Spearman’s correlation was utilized to assess the correlation between the variables. Key findings The majority of participants included 57% men between the age range of 31–45 years (60%) and most of them were diagnosed with Schizophrenia (64%). The results showed that the difference between CMR and MHTT is not significant hence proving that both tools were equally effective. When tested for efficacy, the results showed that the difference was significant (P < .01) thereby concluding that MHTT is more efficacious in the detection of ADEs when compared to CMR. Conclusions From the present study, it can be concluded that the CMR method of detecting ADEs is highly effective while MHTT is a highly efficacious tool.