Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma
Our study demonstrated that HCC tissues exhibited increased levels of PTBP2 expression compared to normal liver tissues. Elevated PTBP2 expression has been identified as closely linked to low survival in patients with HCC and could be a clinically independent prognostic factor. Additionally, PTBP2 may influence the development and forecasting of patients with HCC by altering the TME. Moreover, we confirmed the association between PTBP2 expression and HCC, both in vivo and in vitro.
Authors
- Fengguang Zhai
- Yuxuan Li (ORCID: https://orcid.org/0000-0001-9904-2961)
- Lili Kong (ORCID: https://orcid.org/0000-0002-0674-1155)
- Haipeng Li (ORCID: https://orcid.org/0000-0001-7856-4488)
- Jie Zhu (ORCID: https://orcid.org/0009-0003-2941-3319)
- Xin Jin (ORCID: https://orcid.org/0009-0008-4537-3544)
Institutions
- Ningbo University (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1007/s12672-025-02216-9
- Citations
- 1
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- K. C. Wong Magna Fund in Ningbo University