Validation and expansion of Baveno VII recompensation criteria in patients with cirrhosis and curable liver disease
In recent years, growing evidence has shown that achieving an etiological cure can significantly improve the prognosis of patients with decompensated cirrhosis, leading to the concept of recompensation. The Baveno VII group recently proposed criteria to define recompensation; however, data on the clinical impact of this state remain limited. In this study we evaluated Baveno VII criteria and developed and validated expanded Baveno VII criteria for recompensation. Our findings demonstrate that recompensation is associated with improved survival, reduced hyperdynamic circulation and decreased systemic inflammation in outpatients with decompensated cirrhosis. These results are valuable for hepatologists and researchers aiming to refine patient management strategies and risk stratification in cirrhosis care.
Authors
- N. Zeni
- Paolo Caraceni (ORCID: https://orcid.org/0000-0002-1439-056X)
- Salvatore Piano (ORCID: https://orcid.org/0000-0002-9356-5830)
- Paolo Angeli (ORCID: https://orcid.org/0000-0002-1913-0716)
- Maurizio Baldassarre (ORCID: https://orcid.org/0000-0001-7865-394X)
- Antônio Carlos Accetta
- Marta Tonon (ORCID: https://orcid.org/0000-0001-8913-0992)
- Anna Barone (ORCID: https://orcid.org/0000-0002-9024-5436)
- Giulia Iannone (ORCID: https://orcid.org/0000-0002-3424-1289)
- Roberta Gagliardi (ORCID: https://orcid.org/0000-0002-4275-2783)
- Giacomo Zaccherini (ORCID: https://orcid.org/0000-0002-3219-6963)
- Valeria Calvino (ORCID: https://orcid.org/0009-0003-3789-3092)
- Simone Incicco (ORCID: https://orcid.org/0009-0001-2479-7486)
- Carmine Gabriele Gambino (ORCID: https://orcid.org/0000-0001-9376-1527)
- Enrico Pompili (ORCID: https://orcid.org/0000-0003-2467-7027)
- Gianluca Zilio (ORCID: https://orcid.org/0000-0002-4801-7237)
- Daniele Carrello
Institutions
- University of Padua (IT)
- Azienda USL di Bologna (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1016/j.jhep.2025.04.018
- Citations
- 22
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 29.08
Funders
- Università degli Studi di Padova