SETD1B promotes brain cell ferroptosis in ischemic stroke mice via increasing H3K4me3 enrichment on the Tfrc promoter
These findings suggest that SETD1B enhances ferroptosis in stroke brain cells by a mechanism involving boosting H3K4me3 enrichment at the Tfrc promoter and subsequent upregulation of the expression of Tfrc. Targeting SETD1B may provide a therapeutic strategy for mitigating ferroptosis in stroke.
Authors
- Yiyue Zhang (ORCID: https://orcid.org/0000-0002-9402-3523)
- Kai-Jia Wang
- Huiqi Liu
- Xiu‐Ju Luo (ORCID: https://orcid.org/0000-0002-4605-0148)
- Xisheng Li (ORCID: https://orcid.org/0000-0001-8172-5342)
- Tingting Tang (ORCID: https://orcid.org/0000-0002-1670-7452)
- Jing Tian (ORCID: https://orcid.org/0000-0003-2969-0781)
- Li Wang (ORCID: https://orcid.org/0000-0001-7692-5067)
- Hongrui Liu (ORCID: https://orcid.org/0000-0003-3975-8196)
- Guohui Wei (ORCID: https://orcid.org/0000-0003-1413-7836)
Institutions
- Huaihua University (CN)
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1016/j.lfs.2025.123625
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province