PDGF-BB improves cortical bone quality through restoring the osteogenic microenvironment in the steroid-associated osteonecrosis of rabbits
These findings suggest that PDGF-BB could serve as a potential candidate for attenuating the progression of SAON. Local delivery of PDGF-BB during surgical interventions for SONFH may enhance cortical bone repair and improve mechanical stability, offering a clinically viable strategy to achieve better long-term outcomes.
Authors
- Keda Shi
- Tianluo Ye
- Yiqing Zhao (ORCID: https://orcid.org/0000-0003-2874-8136)
- Jie Hao
- Cuishan Huang
- Xinluan Wang (ORCID: https://orcid.org/0000-0002-9724-4444)
- Ling Qin (ORCID: https://orcid.org/0000-0001-6173-6167)
- Yuxiao Lai (ORCID: https://orcid.org/0000-0002-8648-6595)
- Lingli Li (ORCID: https://orcid.org/0000-0003-0059-9992)
- Jing Long (ORCID: https://orcid.org/0000-0002-0455-1489)
- Yanzhi Liu (ORCID: https://orcid.org/0000-0002-3328-7007)
- Xiangbo Meng (ORCID: https://orcid.org/0000-0003-3417-7480)
- Huijuan Cao
Institutions
- Guangdong Medical College (CN)
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Academy of Mathematics and Systems Science (CN)
- Shenzhen Institutes of Advanced Technology (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1016/j.jot.2025.03.010
- Citations
- 6
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 10.33
Funders
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality
- National Key Research and Development Program of China