A functional seizure case in Wilson’s disease

Wilson's disease (WD) is a rare disorder characterized by abnormal copper metabolism, leading to its accumulation in various tissues, particularly the brain and the liver. Psychiatric and neurological symptoms are common manifestations of WD. We present a case of a 22-year-old woman diagnosed with WD who exhibited neurological symptoms and experienced functional seizures (FS) that were misdiagnosed as epilepsy secondary to WD for almost two years. The patient's history of childhood trauma and interpersonal difficulties underscored the complex interplay between organic and psychogenic factors contributing to FS development. This case highlights the diagnostic challenges associated with the neuropsychiatric manifestations of Wilson's disease, as well as the complexities in differentiating functional seizures from epilepsy. It emphasizes the importance of comprehensive assessment and multidisciplinary care in optimizing patient outcomes.

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Publication Details

Journal
Epilepsy & Behavior Reports
Published
2025-04-13
DOI
https://doi.org/10.1016/j.ebr.2025.100768
Citations
1
Primary Topic
Trace Elements in Health
Type
article
Field-Weighted Citation Impact
1.12
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article

A functional seizure case in Wilson’s disease

Laura D’Andrea, Antônio Chambô Filho, Renato Luiz Marchetti, Raphael Mosqueira
1 citations
Epilepsy & Behavior Reports
Trace Elements in Health
1.12
article

A functional seizure case in Wilson’s disease

Laura D’Andrea, Antônio Chambô Filho, Renato Luiz Marchetti, Raphael Mosqueira
article en
1 citations

Abstract

Wilson's disease (WD) is a rare disorder characterized by abnormal copper metabolism, leading to its accumulation in various tissues, particularly the brain and the liver. Psychiatric and neurological symptoms are common manifestations of WD. We present a case of a 22-year-old woman diagnosed with WD who exhibited neurological symptoms and experienced functional seizures (FS) that were misdiagnosed as epilepsy secondary to WD for almost two years. The patient's history of childhood trauma and interpersonal difficulties underscored the complex interplay between organic and psychogenic factors contributing to FS development. This case highlights the diagnostic challenges associated with the neuropsychiatric manifestations of Wilson's disease, as well as the complexities in differentiating functional seizures from epilepsy. It emphasizes the importance of comprehensive assessment and multidisciplinary care in optimizing patient outcomes.

Epilepsy & Behavior ReportsVol. 30
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Openalex Percentile: Top 25%
Trace Elements in Health
1.12
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