Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques
The influence of Lewy body (LB) and tau co-pathologies is increasingly acknowledged as putatively affecting neurodegeneration and clinical phenotypes. Here, we injected rhesus macaques with LB fractions or/and tau seeds derived from patients brains into distinct brain areas connected to the mesencephalon. Compared to control macaques, we observed increased mesencephalic staining of pathological α-synuclein and tau, as well as nigrostriatal dopaminergic neuronal loss, with a cumulative effect of co-pathology.
Authors
- Benjamin Dehay (ORCID: https://orcid.org/0000-0003-1723-9045)
- Erwan Bézard (ORCID: https://orcid.org/0000-0002-0410-4638)
- Maria Xilouri (ORCID: https://orcid.org/0000-0001-7038-0780)
- Marie-Laure Arotçarena (ORCID: https://orcid.org/0000-0002-1306-3700)
- Morgane Darricau (ORCID: https://orcid.org/0000-0002-6663-3156)
- William A. McEwan (ORCID: https://orcid.org/0000-0002-4408-0407)
- Vincent Planche (ORCID: https://orcid.org/0000-0003-3713-227X)
- Qin Li (ORCID: https://orcid.org/0000-0002-8375-1234)
- Panagiotis Katsinelos (ORCID: https://orcid.org/0000-0001-6951-3216)
- Valentine Kulifaj
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Academy of Athens (GR)
- University of Cambridge (GB)
- Institut des Maladies Neurodégénératives (FR)
- Biomedical Research Foundation of the Academy of Athens (GR)
- University of Clermont Auvergne (FR)
- UK Dementia Research Institute (GB)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Institut Interdisciplinaire de Neuroscience (FR)
- Motac Neuroscience (United Kingdom) (GB)
- BAIC Motor (China) (CN)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2025-04-13
- DOI
- https://doi.org/10.1038/s41531-025-00938-9
- Citations
- 2
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Wellcome Trust
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- Lister Institute of Preventive Medicine
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Université de Bordeaux