Assembly of MSCs into a spheroid configuration increases poly(I:C)-mediated TLR3 activation and the immunomodulatory potential of MSCs for alleviating murine colitis
Collectively, these findings highlight the synergistic benefits of combining 3D spheroid assembly with TLR3 activation as an innovative strategy to improve the therapeutic efficacy of MSC-based treatments for IBD and other inflammatory diseases by increasing post-engraftment cell survival and immunomodulatory capacity.
Authors
- Shyh‐Jier Huang (ORCID: https://orcid.org/0000-0002-9996-8673)
- Han Sheng Chiu (ORCID: https://orcid.org/0000-0003-2248-0845)
- Wan‐Chen Hsieh (ORCID: https://orcid.org/0000-0003-1028-4732)
- Yueh-Ming Shyu (ORCID: https://orcid.org/0000-0002-3338-2020)
- Tzu-Sheng Hsu (ORCID: https://orcid.org/0000-0002-8597-6939)
- I‐Ching Wang (ORCID: https://orcid.org/0000-0003-4398-2975)
- Chieh‐Cheng Huang (ORCID: https://orcid.org/0000-0003-1773-8450)
- Qianyi Liu (ORCID: https://orcid.org/0009-0005-8077-7374)
- Shaowen Liu (ORCID: https://orcid.org/0000-0002-0351-6868)
- Ying‐Chi Kao
- C.‐W. Ho
- Li‐Wen Hsu
Institutions
- National Tsing Hua University (TW)
- Food Industry Research and Development Institute (TW)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s13287-025-04297-3
- Citations
- 5
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- National Health Research Institutes
- National Tsing Hua University
- National Science and Technology Council