Dysregulated lipid metabolism in a retinal pigment epithelial cell model and serum of patients with age-related macular degeneration
This study highlights the significant role of lipid metabolism dysregulation in AMD pathogenesis. The consistent lipidomic alterations observed in RPE cultures and AMD patient serum reinforce their potential as biomarkers for disease progression and therapeutic targets. These findings provide a robust framework for understanding AMD-associated lipid metabolism changes and their systemic impact.
Authors
- Héctor González‐Iglesias (ORCID: https://orcid.org/0000-0001-5251-0967)
- Ana Álvarez-Barrios (ORCID: https://orcid.org/0000-0002-8765-8352)
- Rosario Pereiro (ORCID: https://orcid.org/0000-0002-5936-7726)
- Montserrat García (ORCID: https://orcid.org/0000-0001-9983-546X)
- Lydia Álvarez (ORCID: https://orcid.org/0000-0002-0604-7411)
- Jorge R. Álvarez-Buylla
- Pilar Sáenz de Santa María
Institutions
- Universidad de Oviedo (ES)
- Instituto de Productos Lácteos de Asturias (ES)
- Fernández-Vega Ophthalmological Institute (ES)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s12915-025-02198-8
- Citations
- 11
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 18.78
Funders
- Yale University
- Ministerio de Ciencia e Innovación
- Fundación Rafael del Pino
- Ministerio de Educación y Formación Profesional
- Consejo Superior de Investigaciones Científicas
- Agencia Estatal de Investigación