Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses
Tcf4 controls the balance between Paneth and goblet cells and is essential for antimicrobial peptide production in the small intestine. In colon adenomas, Paneth-like tumor cells drive antimicrobial gene expression and provide Wnt3 ligands, which may have implications for cancer therapy.
Authors
- Konrad Basler (ORCID: https://orcid.org/0000-0003-3534-1529)
- Monika Stastna
- Michal Kolář (ORCID: https://orcid.org/0000-0002-4593-1525)
- Vı́tězslav Křı́ž
- Klara Kostovcikova (ORCID: https://orcid.org/0000-0003-1821-398X)
- Lucie Janečková (ORCID: https://orcid.org/0000-0003-0139-7065)
- Jan Kubovčiak (ORCID: https://orcid.org/0000-0001-6446-9797)
- Tomáš Valenta (ORCID: https://orcid.org/0000-0002-3043-1835)
- Linda Berková
- Štěpán Coufal (ORCID: https://orcid.org/0000-0001-6950-1813)
- Dušan Hrčkulák (ORCID: https://orcid.org/0000-0002-1752-3612)
- Jakub Onhajzer (ORCID: https://orcid.org/0000-0001-6569-6836)
- Vladimír Kořínek (ORCID: https://orcid.org/0000-0002-9777-4664)
- Dominik Filipp (ORCID: https://orcid.org/0000-0003-2506-9330)
- Marketa Tenglerova
- Kateřina Večerková (ORCID: https://orcid.org/0009-0007-7387-8868)
- Stela Dostalikova
- Tereza Mullerova
- Richard S. Blumberg
Institutions
- Brigham and Women's Hospital (US)
- Czech Academy of Sciences (CZ)
- University of Zurich (CH)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Institute of Molecular Genetics (RU)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s13287-025-04280-y
- Citations
- 5
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Foundation for the National Institutes of Health
- European Commission
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Grantová Agentura České Republiky
- Akademie Věd České Republiky
- Central European Institute of Technology
- National Institutes of Health