Pseudoprogression on 68Ga-DOTATATE PET/CT in a Pediatric Patient With Neuroblastoma

A 6-year-old boy with neuroblastoma underwent a 68Ga-DOTATATE PET/CT scan to assess his therapeutic response. The results revealed significant DOTATATE uptake in the right mandible ramus compared with previous scans, indicating potential disease progression. In contrast, 123I-MIBG SPECT/CT imaging demonstrated the resolution of this lesion when compared with earlier MIBG images. This case highlights the possibility of pseudoprogression on 68Ga-DOTATATE PET/CT during the repair process of bone metastatic lesions in neuroblastoma.