Transcriptomics and proteomics reveal associations between myometrium and intrauterine adhesions
Transcriptomic and proteomic data revealed a correlation between endometrial injury and the myometrium. These findings preliminarily revealed that the myometrium possibly contributes to the aetiology and progression of IUAs through dual mechanisms. On the one hand, the myometrium inhibits endometrial regeneration by suppressing the cell mitogenic pathway. On the other hand, it promotes fibrosis by activating the complement-coagulation cascade system and inhibiting the ECM degradation pathway. These new findings increase our understanding of the pathogenesis of IUAs and potentially contribute to the application of precision clinical treatment for IUAs.
Authors
- Xianghua Huang (ORCID: https://orcid.org/0000-0002-0104-4318)
- Xianghang Sun
- Yanpeng Tian (ORCID: https://orcid.org/0000-0001-8049-1281)
- Mingle Zhang (ORCID: https://orcid.org/0000-0002-2890-4605)
- Kaixuan Guo (ORCID: https://orcid.org/0009-0008-7144-4684)
- Peng Zhao (ORCID: https://orcid.org/0000-0002-1023-6311)
- Fen Li (ORCID: https://orcid.org/0000-0002-0115-3784)
- Pan Zhao (ORCID: https://orcid.org/0009-0005-7118-5430)
- Xiaotong Xu (ORCID: https://orcid.org/0000-0001-9571-0942)
- Jiahua Zheng
- Xuemei Zhang (ORCID: https://orcid.org/0009-0003-5419-5640)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Cangzhou Central Hospital (CN)
- Fourth Hospital of Hebei Medical University (CN)
- First Hospital of Shijiazhuang (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- BMC Women s Health
- Published
- 2025-04-11
- DOI
- https://doi.org/10.1186/s12905-025-03661-y
- Citations
- 3
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.09
Funders
- Health Commission of Hebei Province
- Hebei Medical University