Memory-promoting function of miR-379-5p attenuates CD8<sup>+</sup> T cell exhaustion by targeting immune checkpoints
MiR-379-5p acts as an epigenetic tumor suppressor by enhancing CD8<sup>+</sup> T cell effector functions and suppressing T cell exhaustion. MiR-379-5p could represent a novel marker and strategy for cancer immunotherapy, offering promising avenues for enhancing antitumor immune responses.
Authors
- Chia-Hsin Liu (ORCID: https://orcid.org/0000-0002-2880-8365)
- Shao‐Chun Wang (ORCID: https://orcid.org/0000-0002-5477-1682)
- Ting-Yi Liao
- Wanrong Wu
- Yichun Shen (ORCID: https://orcid.org/0000-0003-4519-6097)
- Guan‐Yu Zhuo (ORCID: https://orcid.org/0000-0002-9813-2989)
- Chuan-Chun Lee
- Wei‐Chung Cheng (ORCID: https://orcid.org/0000-0002-1229-4857)
- Liang‐Chih Liu (ORCID: https://orcid.org/0000-0002-2594-0109)
- Hongwei Li (ORCID: https://orcid.org/0000-0003-2543-3577)
- You‐Zhe Lin
- Feng-Chi Chung
Institutions
- Asia University (TW)
- China Medical University (TW)
- China Medical University Hospital (TW)
- University of Cincinnati (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010363
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- China Medical University Hospital
- China Medical University