Targeting B7-H3 inhibition-induced activation of fatty acid synthesis boosts anti-B7-H3 immunotherapy in triple-negative breast cancer
Our findings propose an "immune attack-metabolic compensation" dynamic model and suggest the feasibility of a dual-targeting strategy that concurrently inhibits both B7-H3 and FASN to enhance therapeutic efficacy in TNBC patients.
Authors
- Jie Mei (ORCID: https://orcid.org/0000-0001-7799-8129)
- Xiaoqian Zhao (ORCID: https://orcid.org/0000-0002-4865-3372)
- Zhiwen Qian (ORCID: https://orcid.org/0000-0002-1679-2407)
- C Wang (ORCID: https://orcid.org/0000-0002-0243-5409)
- Xin Ning (ORCID: https://orcid.org/0000-0001-7897-1673)
- Lu Liu (ORCID: https://orcid.org/0000-0003-3289-8671)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-7983-8396)
- Danping Wu
- Ying Jiang (ORCID: https://orcid.org/0000-0003-3253-6400)
- Yilan You
Institutions
- Jiangnan University (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010924
- Citations
- 8
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 8.36
Funders
- National Natural Science Foundation of China