Allogeneic hematopoietic stem cell transplantation for pediatric acute leukemia: single center experience in 150 pediatric patients transplanted in 2021-2023
Introduction: Allogeneic hematopoietic stem cell transplantation (aHSCT) is an effective and safe option for treatment of pediatric acute leukemia.Key factors for successful aHSCT in children are the combination of transplant technologies and supportive care.Methodology: This is a retrospective analysis of 150 pediatric aHSCT for acute leukemia in Nikolay Blokhin National Medical Research Center of Oncology in 2021-2023.We aimed to define the type and cumulative incidence of complications after aHSCT for acute leukemia, as well as the overall outcomes: overall (OS) and event-free (EFS) survival.Results: Data were received from 145 children (median of age 8.5 years, range 0.2-17) who received 150 aHSCT.Media follow-up was 23.5 months .Indications included acute lymphoblastic leukemia (ALL, 66.6%), acute myeloid leukemia (AML, 30.1%), and mixed-phenotype acute leukemia (MPAL, 3.3%).Conditioning regimens: ALL -TBI 12 Gy+VP+Flu, AML/MPAL: Treo+Thio+Flu.Donors: Haploidentical (haplo) -43.7%, match related donor (MRD) -30.2%, matched unrelated donor (MUD) -26.1%.TCR a/b/CD19 depletion was made in 56.5% of haplo, other aHSCT-PtCy.
Authors
- Meri Shervashidze
- Mariya Malova (ORCID: https://orcid.org/0000-0003-2140-0858)
- Т. Т. Валиев (ORCID: https://orcid.org/0000-0002-1469-2365)
- И. О. Костарева (ORCID: https://orcid.org/0000-0003-0179-2479)
- С. Р. Варфоломеева (ORCID: https://orcid.org/0000-0001-6131-1783)
- K. V. Mitrakov (ORCID: https://orcid.org/0000-0002-2010-5534)
- Daria Smirnova (ORCID: https://orcid.org/0000-0002-0090-1891)
- Ramil Fatkhullin (ORCID: https://orcid.org/0000-0001-5988-8428)
- Е. Б. Мачнева (ORCID: https://orcid.org/0000-0003-2395-4045)
- К. А. Сергеенко (ORCID: https://orcid.org/0000-0003-3225-8412)
- E. I. Shirikov (ORCID: https://orcid.org/0000-0002-5663-4032)
- К. И. Киргизов (ORCID: https://orcid.org/0000-0002-2945-284X)
- N. G. Stepanyan (ORCID: https://orcid.org/0000-0001-7939-5129)
- N. A. Burlaka (ORCID: https://orcid.org/0000-0002-3289-223X)
- Timur A. Aliev (ORCID: https://orcid.org/0000-0002-2878-7680)
- Natalia A. Batmanova (ORCID: https://orcid.org/0000-0002-5728-2243)
- A. Yu. Elfimova (ORCID: https://orcid.org/0000-0001-8143-5791)
- I. Yu. Trushkova (ORCID: https://orcid.org/0009-0000-5828-8041)
- Vasily Grigorenko
- V. Yu. Ermakova
- Egor Ranev
- Yuriy Lozovan
Institutions
- National Medical Research Center of Cardiology (RU)
Publication Details
- Journal
- OncoDaily Medical Journal
- Published
- 2025-01-01
- DOI
- https://doi.org/10.69690/odmj-018-0425-1342
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00