Cortical, subcortical, brainstem and autonomic responses to nociception under total intravenous anesthesia
PRD, HR, and BIS correlated with varying levels of remifentanil, with PRD exhibiting the strongest correlation. When CE remifentanil are low, noxious stimuli are more likely to dilate the pupil and be detected in the EEG. Considering the complexity of the nociceptive response, integrating multimodal neurophysiologic monitoring with pharmacological data may improve the anesthesiologist's ability to assess on the nociception-antinociception balance. However, further studies are needed to validate these findings and address the study's limitations.
Authors
- Pedro L. Gambús (ORCID: https://orcid.org/0000-0001-8802-6237)
- Paul S. García (ORCID: https://orcid.org/0000-0001-5544-6251)
- Matthias Kreuzer (ORCID: https://orcid.org/0000-0003-2472-3556)
- Pedro Amorim (ORCID: https://orcid.org/0000-0001-7466-4174)
- Gerhard Schneider (ORCID: https://orcid.org/0000-0002-4903-0118)
- Mafalda Couto (ORCID: https://orcid.org/0000-0002-4057-8355)
- Sérgio Vide (ORCID: https://orcid.org/0000-0002-8185-2250)
- Sebastián Jaramillo (ORCID: https://orcid.org/0000-0002-5933-3358)
- Ana Ferreira (ORCID: https://orcid.org/0000-0003-2350-6947)
- Iñaki F. Trocóniz (ORCID: https://orcid.org/0000-0003-3700-8658)
- Merlín D. Larson (ORCID: https://orcid.org/0000-0003-0415-3576)
- Fernando Abelha
- Mercé Agustí
Institutions
- NewYork–Presbyterian Hospital (US)
- University of California, San Francisco (US)
- Universidade do Porto (PT)
- Columbia University Irving Medical Center (US)
- TUM Klinikum (DE)
- Hospital de São João (PT)
- Navarre Institute of Health Research (ES)
- Hospital Clínic de Barcelona (ES)
- Institute of Mechanical Engineering and Industrial Mangement (PT)
- Centro Hospitalar do Porto (PT)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Technical University of Munich (DE)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Journal of Clinical Anesthesia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.jclinane.2025.111825
- Citations
- 8
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 17.53