Stable overexpression of the epithelial sodium channel alpha subunit reduces migration and proliferation in breast cancer cells
Higher αENaC expression correlates with improved patient outcomes, and overexpression in breast cancer cells reduces both cell migration and proliferation. These results highlight the possibility of ENaC as a target for future breast cancer treatments.
Authors
- Wey Qi Chin
- Sarah McQueen
- Fiona J. McDonald (ORCID: https://orcid.org/0000-0001-9242-166X)
- Heather E. Cunliffe (ORCID: https://orcid.org/0000-0003-3930-4004)
Institutions
- University of Otago (NZ)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1007/s10549-025-07667-w
- Citations
- 1
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- University of Otago