[Comprehensive Analysis of the Expression, Prognosis and Function of TRAF Family Proteins in NSCLC].
TRAF family members exhibit highly specific expression differences across different tissues and cancer types. Most TRAF proteins exhibit upregulation at both mRNA and protein levels in NSCLC, whereas, only upregulated expressions of TRAF2, TRAF4 and TRAF7 predict worse prognosis. The TRAF family members regulate processes such as inflammation, immunity, adhesion and splicing, and influence the tumor immune microenvironment.
Authors
- Hongli Pan (ORCID: https://orcid.org/0000-0001-9205-1232)
- Xuexia Zhou (ORCID: https://orcid.org/0000-0001-6644-5625)
- Yaguang Fan (ORCID: https://orcid.org/0000-0001-7246-8858)
- Xiuwen Zhang (ORCID: https://orcid.org/0000-0003-1003-2885)
- Yixuan Wang (ORCID: https://orcid.org/0000-0002-2961-6760)
- Qiang Chen (ORCID: https://orcid.org/0000-0002-2398-4482)
- Xuebing Li (ORCID: https://orcid.org/0000-0001-8903-9793)
- Sheng-Lung Tu (ORCID: https://orcid.org/0009-0004-2273-9452)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-9081-0802)
Institutions
- Tianjin Medical University General Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-20
- DOI
- https://doi.org/10.3779/j.issn.1009-3419.2025.102.09
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article