The investigation of effects, signal pathways, and applications of high glucose on dental pulp stem cells
The present study demonstrated that while HG slightly impairs DPSC viability, it promotes osteogenic, adipogenic, and neurogenic differentiation. Providing valuable insights into the mechanisms by which HG influences various differentiation pathways in DPSCs and establishes a foundation for potential clinical applications of DPSCs in regenerative medicine for diabetic patients.
Authors
- Ming‐Hua Ho (ORCID: https://orcid.org/0000-0001-6620-4207)
- I‐Hsun Li (ORCID: https://orcid.org/0000-0002-2824-4774)
- Chung-Hsing Li (ORCID: https://orcid.org/0000-0002-6718-5500)
- Wei-Cheng Tsai
- Shih‐Yu Lee (ORCID: https://orcid.org/0000-0002-4713-6410)
Institutions
- Tri-Service General Hospital (TW)
- National Taiwan University of Science and Technology (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1016/j.jds.2025.03.038
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- National Taiwan University of Science and Technology
- Tri-Service General Hospital