Detection of a novel SME-6 Carbapenemase in <i>Serratia ureilytica</i> in Germany
To the best of our knowledge, this study reports the first identification of SME-6 and the first detection of an SME-type carbapenemase in Germany. Resistance was found to be temperature-dependent, with faster growth and higher SME-6 expression at lower temperatures contributing to the phenotype. These findings suggest SME variants may be underdiagnosed using current diagnostic protocols, highlighting the need for adjustments to improve detection of temperature-sensitive resistance mechanisms.
Authors
- Leif Tüeffers
- Sébastien Boutin (ORCID: https://orcid.org/0000-0002-0499-2460)
- Susanne Hauswaldt
- Lisa Göpel
- Dennis Nurjadi (ORCID: https://orcid.org/0000-0002-1278-5939)
- Kaan Kocer (ORCID: https://orcid.org/0000-0002-1134-4197)
- Jan Rupp (ORCID: https://orcid.org/0000-0001-8722-1233)
- Sarah Gisch
Institutions
- University Hospital Schleswig-Holstein (DE)
- German Center for Infection Research (DE)
- German Center for Lung Research (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1093/jac/dkaf121
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.18