Molecular mechanisms of the Xiao-chai-hu-tang on chronic stress-induced colorectal cancer growth based on an integrated network pharmacology and RNA sequencing approach with experimental validation
XCHT could reverse the tumor energy metabolism reprogramming and improve the inflammatory microenvironment in CRC under chronic stress through the IL-6/JAK2/STAT3 pathway. Therefore, XCHT might represent a promising therapeutic strategy for suppressing psychologically associated CRC progression.
Authors
- Zhongya Ni
- Yiyang Zhao (ORCID: https://orcid.org/0000-0002-3077-9401)
- Yingru Zhang (ORCID: https://orcid.org/0000-0001-8742-0267)
- Zhaozhou Zhang (ORCID: https://orcid.org/0009-0009-4105-6864)
- Dongming Hua
- Yan Wang (ORCID: https://orcid.org/0000-0002-1210-0258)
- Ying Feng (ORCID: https://orcid.org/0009-0001-0822-2754)
- Yun‐Feng Guan
- Wang Yao
- Haidong Guo (ORCID: https://orcid.org/0000-0001-9346-6819)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s12906-025-04860-8
- Citations
- 2
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.11