<i>APOE</i> and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos
The apolipoprotein E (APOE) ε4 effect is stronger in Peruvians/Bolivians than in other Hispanic/Latino groups. The strong APOE effect size in Peruvians and Bolivians was replicated in a second independent Peruvian cohort. Meta-analysis for ε4 and ε2 confirmed a significant association with Alzheimer's disease and related dementias (ADRD). Global and local ancestry do not modify the association between APOE genotype and ADRD.
Authors
- Mario Cornejo‐Olivas (ORCID: https://orcid.org/0000-0001-6313-5680)
- Nilton Custodio (ORCID: https://orcid.org/0000-0002-8025-3272)
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Victoria Marca
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Rebeca Wong (ORCID: https://orcid.org/0000-0001-7287-0660)
- Robert C. Barber (ORCID: https://orcid.org/0000-0001-6857-0286)
- Basilio Cieza
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Rosa Montesinos (ORCID: https://orcid.org/0000-0002-9342-8756)
- Sandra Barral (ORCID: https://orcid.org/0000-0001-5623-4939)
- Sid E. O’Bryant (ORCID: https://orcid.org/0000-0003-0582-5266)
- Nicole Phillips (ORCID: https://orcid.org/0000-0002-9324-2687)
- Marcio Soto‐Añari (ORCID: https://orcid.org/0000-0002-9121-3284)
- Juan Carlos Durán (ORCID: https://orcid.org/0000-0002-8837-2540)
- Maria Cusicanqui
- Zikun Yang (ORCID: https://orcid.org/0000-0002-8834-6377)
- Silvia Mejía-Arango (ORCID: https://orcid.org/0000-0002-6416-1159)
- Alejandra Michaels Obregón
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Rafael Samper‐Ternent (ORCID: https://orcid.org/0000-0002-2250-9401)
- Ivonne Z. Jiménez Velázquez
- Dolly Reyes‐Dumeyer (ORCID: https://orcid.org/0000-0003-3572-8248)
- Margaret A. Pericak‐Vance
- Farid Rajabli
- Lawrence S. Honig
Institutions
- Universidad Mayor de San Andrés (BO)
- University of North Texas (US)
- NewYork–Presbyterian Hospital (US)
- University of Miami (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- University of North Texas Health Science Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- Universidad Privada San Juan Bautista (PE)
- Universidad Científica del Sur (PE)
- The University of Texas Rio Grande Valley (US)
- Longevity Biotech (United States) (US)
- Dr. John T. Macdonald Foundation (US)
- Universidad Católica San Pablo (PE)
- Instituto Nacional de Ciencias Neurológicas
- Columbia University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70138
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- National Institutes of Health
- National Institute on Aging