Cognitive and behavioral benefits of 2′-fucosyllactose in growing mice: the roles of 5-hydroxytryptophan and gut microbiota
This study offers preliminary evidence that the cognitive-promoting effects of 2'-FL in mice may be closely associated with gut microbiota and 5-HT. The findings suggest that 2'-FL contribute to cognitive development in growing mice, potentially by modulating gut microbiota and enhancing 5-HT levels in the brain. Video Abstract.
Authors
- Ting F Luo (ORCID: https://orcid.org/0000-0002-3394-7861)
- Liuying Zhu
- Liufeng Zheng (ORCID: https://orcid.org/0000-0003-2648-2653)
- Zeyuan Deng (ORCID: https://orcid.org/0000-0001-5650-1507)
- Jing Li (ORCID: https://orcid.org/0000-0002-8850-454X)
- Bing Zhang
- Hongyan Li (ORCID: https://orcid.org/0000-0002-1153-7554)
- Zhiyi Zhang (ORCID: https://orcid.org/0000-0002-9853-9359)
- Jinqiang Liao
- Minghui Wang
Institutions
- Nanchang University (CN)
- State Key Laboratory of Food Science and Technology (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s40168-025-02094-x
- Citations
- 10
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 11.20
Funders
- State Key Laboratory of Food Science and Technology