Effects of taxane-anthracycline and taxane only treatment on cardiac function in breast cancer—a retrospective cohort study
Our study confirms the overall safety on cardiac function of both single taxane and anthracycline plus taxane chemotherapy, as we found no changes in echocardiographic parameters associated with single taxane therapy, while anthracycline plus taxane chemotherapy was associated with a temporary and clinically insignificant reduction of ejection fraction and deceleration time over 1.5 years of follow-up. Our study is limited by its retrospective nature and the low number of participants.
Authors
- Dorottya Mühl
- Viktor J. Horváth (ORCID: https://orcid.org/0000-0002-7888-2651)
- Magdolna Dank (ORCID: https://orcid.org/0000-0002-4694-3624)
- István Takács (ORCID: https://orcid.org/0000-0002-0847-3844)
- Gyöngyvér Szentmártoni (ORCID: https://orcid.org/0000-0003-1093-4619)
- D Fogarasi
- Ádám G. Tabák (ORCID: https://orcid.org/0000-0002-6234-3936)
- Emese Szelke
- Árpád Kézdi
- Gergely Szabó
Institutions
- Semmelweis University (HU)
- University College London (GB)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s40959-025-00335-4
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Semmelweis Egyetem