Incidence of PEG-Asparaginase-Induced Pancreatitis in Children During Acute Lymphoblastic Leukemia Treatment: A Multicenter Study

Introduction: Acute Lymphoblastic Leukemia (ALL) is the most common childhood malignancy worldwide.PEG-Asparaginase (PEG-ASPA) is a cornerstone in ALL chemotherapy, significantly improving survival outcomes.However, it is associated with severe adverse effects, including acute pancreatitis (AP).The incidence and risk factors of AP in children with ALL in Saudi Arabia have not been extensively studied.This study aims to determine the prevalence of AP and identify associated risk factors among pediatric ALL patients receiving PEG-ASPA-based treatment in Saudi Arabia.