Characterizing visual read tau‐PET‐negative participants with Alzheimer's disease dementia
We used the novel Food and Drug Administration (FDA)-approved VR method for defining tau-PET positivity. AD A+T- patients were older and showed less atrophy and cognitive decline than AD A+T+. We did not find convincing evidence of tau accumulation in AD A+T- or copathologies. The group of AD A+T- patients is likely very heterogeneous.
Authors
- Roos M. Rikken (ORCID: https://orcid.org/0000-0002-1357-2572)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Philip Scheltens (ORCID: https://orcid.org/0000-0002-1046-6408)
- Denise Visser (ORCID: https://orcid.org/0000-0002-3642-146X)
- Ronald Boellaard (ORCID: https://orcid.org/0000-0002-0313-5686)
- Pieter Jelle Visser (ORCID: https://orcid.org/0000-0001-8008-9727)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Emma M. Coomans (ORCID: https://orcid.org/0000-0002-4289-9101)
- Elsmarieke van de Giessen
- Anouk den Braber (ORCID: https://orcid.org/0000-0002-3377-2627)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Sandeep S.V. Golla (ORCID: https://orcid.org/0000-0002-0721-7160)
- Everard G.B. Vijverberg (ORCID: https://orcid.org/0000-0003-3879-884X)
- Lyduine E. Collij
- Lotte A. de Koning
- Eline Neutelings
Institutions
- Lund University (SE)
- Karolinska Institutet (SE)
- Maastricht University (NL)
- Amsterdam Neuroscience (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.14423
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Disease Neuroimaging Initiative
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- ZonMw
- Stichting Dioraphte
- Alzheimer Nederland
- Amsterdam Neuroscience
- National Institutes of Health
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Janssen Pharmaceuticals