Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative
We established an open-access African Somatic and Stem Cell Bank. 10 induced pluripotent stem cell lines from five Nigerian ethnic groups were rigorously characterized. Clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein 9 technology was used to introduce frontotemporal dementia-causing MAPT mutations. The African Somatic and Stem Cell Bank is a renewable, genetically diverse resource for neurodegenerative research.
Authors
- Celeste M M. Karch (ORCID: https://orcid.org/0000-0002-6854-5547)
- Ekaterina Aladyeva (ORCID: https://orcid.org/0000-0002-3483-6944)
- Oscar Harari (ORCID: https://orcid.org/0000-0002-2635-6975)
- Miguel Minaya (ORCID: https://orcid.org/0000-0002-2573-6087)
- Nadia Miller
- Jacob Marsh (ORCID: https://orcid.org/0000-0003-3576-6949)
- Mahmoud Bukar Maina (ORCID: https://orcid.org/0000-0002-7421-3813)
- Louise C. Serpell (ORCID: https://orcid.org/0000-0001-9335-7751)
- Selina Wray (ORCID: https://orcid.org/0000-0003-3062-7050)
- Zaid Muhammad (ORCID: https://orcid.org/0000-0002-3976-9840)
- Murtala Bindawa Isah (ORCID: https://orcid.org/0000-0001-8883-3354)
- Scott D. Lee (ORCID: https://orcid.org/0000-0001-8936-8052)
- Larema Babazau
- Katherine Miller (ORCID: https://orcid.org/0000-0003-1438-5717)
- Baba Waru Goni (ORCID: https://orcid.org/0000-0001-9540-091X)
- Emma Starr
- Abdulrahman Alkhamis Idris
Institutions
- University of Sussex (GB)
- Washington University in St. Louis (US)
- The Ohio State University Wexner Medical Center (US)
- Yobe State University (NG)
- Umaru Musa Yar'adua University (NG)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70145
- Citations
- 1
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Alzheimer's Association
- Wellcome Trust
- Hope Center for Neurological Disorders
- Rainwater Charitable Foundation
- University College London
- National Institutes of Health
- Tau Consortium
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke