The combination of CA125, CA199, CEA, and AFP is an effective diagnostic biomarker for gastric cancer in elderly individuals
The levels of serum TMs, including CA12-5, CEA, CA199 and AFP, are elevated in elderly individuals with GC, indicating a higher TNM stage. The combination of CEA, CA12-5, CA199 and AFP has enhanced diagnostic value for GC, thereby offering significant clinical guidance. However, this study is limited by its retrospective design and lack of external validation, which should be addressed in future prospective trials.
Authors
- Hui-ling Ye
- Xiao-Wen Yuan (ORCID: https://orcid.org/0000-0002-0499-1484)
- Dandan Huang (ORCID: https://orcid.org/0000-0002-2594-8434)
- Ping Chen (ORCID: https://orcid.org/0000-0002-8068-1891)
- Licai Deng (ORCID: https://orcid.org/0000-0001-9073-9914)
- Zhengbin Lu
- Jiahao Feng
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1186/s12957-025-03789-z
- Citations
- 1
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.52