Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells
These findings indicate that PTEN loss coupled with PI3K/AKT/mTOR-mediated autophagy inhibition and apoptosis in DPCs is a key mechanism of stress-related hair loss induced by CRH and suggests that topical activation of PTEN or enhancement of autophagy, e.g. through rapamycin, may have a therapeutic effect on stress-induced hair loss disorders such as alopecia.
Authors
- Xiuwen Chen
- Changmin Lin (ORCID: https://orcid.org/0009-0000-9248-1443)
- Keng Huang (ORCID: https://orcid.org/0009-0006-4785-6449)
- Chutong Zhuang
- Ziqing Xu (ORCID: https://orcid.org/0000-0002-6593-4432)
- Wenzi Liang (ORCID: https://orcid.org/0000-0003-4013-1374)
- Yingshi Li (ORCID: https://orcid.org/0000-0001-5698-3374)
- Na Ni (ORCID: https://orcid.org/0000-0003-2955-9310)
- Zhiying Yu
Institutions
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1080/07853890.2025.2490823
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China