Multivariate Pattern Analysis of <scp>fMRI</scp> Reveals Striato‐Cortical Network Changes in Myoclonus‐Dystonia

The task-related effects observed in M-D patients support the involvement of the basal ganglia-thalamo-cortical network. Notably, cerebellar involvement was not strongly implicated in our study. We postulate that inherent deficits in the putamen trigger either premature or downstream compensatory (motor) cortical effects. The potential involvement of the visual cortex in the M-D pathophysiology is new, but its role has been suggested by a previous study investigating visual sensory processing in SGCE gene-positive M-D patients. Our findings, including the innovative searchlight method, pave the way for further studies investigating the complex interplay between brain regions and networks and their role in M-D pathogenesis.