Intermedin protects peritubular capillaries by inhibiting eNOS uncoupling through AMPK/GTPCH-I/BH4 pathway and alleviate CKD following AKI
We concluded that IMD inhibits AKI-CKD transition by protecting endothelial cells of PTC via AMPK/GTPCH-I/BH4/eNOS pathway.
Authors
- Dan Niu (ORCID: https://orcid.org/0000-0002-0715-7946)
- Hui Lin (ORCID: https://orcid.org/0000-0003-1716-1399)
- Xi Qiao (ORCID: https://orcid.org/0000-0002-5264-3425)
- Ruihua Shen (ORCID: https://orcid.org/0000-0002-6457-5829)
- Xiaole Su (ORCID: https://orcid.org/0009-0002-3781-8773)
- Weixia Han
- Ye He (ORCID: https://orcid.org/0000-0002-8801-1817)
- Xiaoli Han (ORCID: https://orcid.org/0000-0002-5421-2135)
- Xiaomei Bai (ORCID: https://orcid.org/0000-0001-9826-4802)
- Li Fan (ORCID: https://orcid.org/0000-0003-1780-6919)
- Junhua Zhang (ORCID: https://orcid.org/0000-0001-7028-0632)
- Xinyuan Feng
- Ge Yuan
- Juan Pan
- Ling Lin (ORCID: https://orcid.org/0000-0002-8573-1608)
Institutions
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-04-12
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.04.015
- Citations
- 4
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.66