Measuring time saved in Alzheimer's disease: What is a meaningful slowing of progression?
AD slowing of clinical progression by 5%-95% resulted in 0.74-17 months saved and 0.08-1.5 CDR-SB points change at 18 months.Slowing of at least 60% or 11 months of time saved over 18 months met an often-cited MCID threshold of 0.98 points for mild cognitive impairment.For mild AD dementia, an MCID of 1.63 meant that even an 18-month delay over 18 months would be considered only borderline meaningful-a face invalid and unrealistic proposition.
Authors
- Thomas Maltesen (ORCID: https://orcid.org/0000-0002-3988-2456)
- Alireza Atri (ORCID: https://orcid.org/0000-0003-4405-6973)
- Linus Jönsson (ORCID: https://orcid.org/0000-0001-5751-6292)
- Anders Gustavsson (ORCID: https://orcid.org/0000-0002-2147-2969)
- Pepa Polavieja
- Soeren Mattke (ORCID: https://orcid.org/0000-0003-4666-9132)
- Julie Hviid Hahn‐Pedersen
- Krista L. Lanctôt (ORCID: https://orcid.org/0000-0001-7024-6637)
- Russ Paulsen
- Teresa León (ORCID: https://orcid.org/0000-0001-5171-4159)
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of Toronto (CA)
- Novo Nordisk (Denmark) (DK)
- Banner Health (US)
- Karolinska Institutet (SE)
- UsAgainstAlzheimer (US)
- Banner Sun Health Research Institute (US)
- Quantify Research (Sweden) (SE)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70081
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Eli Lilly and Company
- Pfizer
- Biogen
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Novo Nordisk
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Institute of Biomedical Imaging and Bioengineering