Transcriptomic miRNA and mRNA signatures in primary prostate cancer that are associated with lymph‐node invasion
Primary prostate cancer (PCa) tumours from patients pathologically diagnosed as N0 (pN0) or N1 (pN1) were dually assessed for microRNA (miRs) and mRNA levels using an NGS-based assay. A four-mRNA and an eight-miRNA signature were found. The mRNA signatures were further validated using two datasets. The combination of serum prostate-specific antigen (PSA) levels or Grade Group with the miR/mRNA signatures separates pN1 from pN0 PCa patients.
Authors
- SooMin Kim
- Timothy G. Wilson (ORCID: https://orcid.org/0009-0002-9647-7550)
- Dave S.�B. Hoon (ORCID: https://orcid.org/0000-0003-1915-3683)
- David L. Krasne
- Romela Irene Ramos
- Warren M. Allen
- Yoko Koh (ORCID: https://orcid.org/0000-0001-9976-6994)
- Kelly K. Chong
- Matías A. Bustos (ORCID: https://orcid.org/0000-0001-9625-1127)
- Gianna Jimenez
- Eleanor Ziarnik
Institutions
- Providence College (US)
- Saint John's Health Center (US)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/ctm2.70288
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94